Staff Scientist

Guidehouse

Bethesda, USonsite$98k-$163k/yrPosted Aug 6, 2026
Posting intelligenceActively listed

About the role

Job Family: Scientist

Travel Required: None

Clearance Required: Ability to Obtain Public Trust

What You Will Do:

We are currently searching for a Staff Scientist to provide laboratory leadership and support services to perform interdisciplinary and collaborative research from bench to beside with the National Heart, Lung, and Blood Institute (NHLBI). This is a full-time, on-site opportunity in Bethesda, MD.

Combine biochemical, molecular, cellular, genetic, and quantitative approaches to investigate fundamental biological processes across a range of organisms, including fish, flies, mice, mammals, microbes, and viruses.

Gain an understanding on how cells sense, respond, and adapt to a variety of stress conditions, including nutrient deprivation, organelle damage, and pathogen infection.

Address how alterations in mTOR, TFEB, TFE3, and lysosomal function lead to human disease.

Seek to identify potential sites for therapeutic intervention suitable for further evaluation in translational and clinical research efforts.

Contribute to training and mentoring of all laboratory members.

What You Will Need:

PhD with at least TWO (2) years of postdoctoral research experience in molecular biology, cellular biology, biochemistry, or related field OR

Master’s degree with at least FIVE (5) years of intensive, hands-on research experience in molecular biology, cellular biology, biochemistry, or related field in lieu of PhD

Must have a mastery of Zebrafish models with skills such as husbandry, genetic crossing, and genotyping protocols.

Must have a have a strong publication record.

Experience working with other animal models.

Expertise in cellular biology and microscopy imaging.

Must be able to obtain and maintain a Federal or DoD Public Trust. Candidates must receive approved adjudication of their Public Trust prior to onboarding with Guidehouse. Candidates with an active Public Trust or existing suitability are preferred.

What Would Be Nice To Have:

Advanced skills in light microscopy are strongly desired.

Knowledge of organelle cell biology (lysosomes, autophagy, intracellular trafficking), and a commitment to conducting related high-quality research.

Able to work independently and in a team setting.

Excellent verbal and written communication abilities.

Outstanding interpersonal and time management skills.

Demonstrated experience in staff training and mentoring.

The annual salary range for this position is $98,000.00-$163,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

Medical, Rx, Dental & Vision Insurance

Personal and Family Sick Time & Company Paid Holidays

Parental Leave

401(k) Retirement Plan

Group Term Life and Travel Assistance

Voluntary Life and AD&D Insurance

Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

Transit and Parking Commuter Benefits

Short-Term & Long-Term Disability

Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

Employee Referral Program

Corporate Sponsored Events & Community Outreach

Care.com annual membership

Employee Assistance Program

Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.

Compensation

This Other role pays $98k-$163k/yr. Within typical range for other roles in United States.

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